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Deep expertise across FDA-regulated sectors

We specialize in mid-market companies with $5M–$100M revenue who need professional compliance support without enterprise-level costs. Every industry has unique regulatory requirements — we know them all.

Pharmaceutical Manufacturers

Pharmaceutical companies face some of the most rigorous FDA oversight in any industry. From raw material qualification to final product release, every step requires documented compliance with current Good Manufacturing Practices.

ADF provides continuous monitoring of your cGMP systems, documentation practices, and quality controls — ensuring you're always prepared for both announced and unannounced FDA inspections.

Key Regulations

21 CFR Part 211cGMPICH Q7Drug Supply Chain

Common Audit Challenges

  • Inadequate documentation and batch record review processes
  • CAPA systems that don't demonstrate root cause analysis
  • Training program gaps and missing competency records
  • Environmental monitoring and contamination control deficiencies
  • Supplier qualification and incoming material testing failures

Medical Device Companies

Medical device manufacturers operate under the Quality System Regulation with design controls, production controls, and post-market surveillance requirements that demand meticulous documentation and process validation.

ADF helps device companies maintain QSR compliance across the full product lifecycle — from design inputs through manufacturing, complaint handling, and CAPA management.

Key Regulations

21 CFR Part 820QSRDesign Controls510(k)MDR

Common Audit Challenges

  • Incomplete design history files and traceability matrices
  • Process validation gaps in manufacturing procedures
  • Complaint handling systems that miss reportable events
  • Document control failures and unauthorized changes
  • Risk management files not maintained per ISO 14971

Compounding Pharmacies

The regulatory landscape for compounding pharmacies has intensified dramatically. 503A and 503B facilities face increasing FDA scrutiny around sterility assurance, beyond-use dating, and facility controls.

ADF provides specialized compliance support for compounding operations, including sterile processing oversight, environmental monitoring programs, and preparation for state board and FDA inspections.

Key Regulations

503A / 503BUSP <797>USP <800>cGMP for Outsourcing

Common Audit Challenges

  • Sterility assurance failures and contamination events
  • Environmental monitoring not meeting USP standards
  • Beyond-use dating without adequate stability data
  • Personnel qualification and aseptic technique deficiencies
  • Inadequate adverse event reporting systems

Nutraceutical Producers

Dietary supplement manufacturers face growing FDA enforcement around cGMP compliance, label claims, and identity testing. The days of light-touch regulation in this sector are ending.

ADF helps nutraceutical companies build robust quality systems that satisfy both FDA expectations and increasingly demanding retailer audit requirements.

Key Regulations

21 CFR Part 111DSHEAcGMP for SupplementsLabel Claims

Common Audit Challenges

  • Identity testing failures for raw materials and finished products
  • Inadequate specifications and master manufacturing records
  • Label claim substantiation gaps
  • Batch record review and release procedure deficiencies
  • Supplier qualification programs that don't meet cGMP

Contract Manufacturers

CMOs and CDMOs face a unique challenge: maintaining compliance across multiple clients, multiple products, and often multiple regulatory frameworks simultaneously. A single audit finding can impact every client relationship.

ADF provides multi-client compliance coordination, ensuring your quality systems satisfy the requirements of every product you manufacture — and every customer who audits you.

Key Regulations

cGMP (varies by product)Quality Agreements21 CFR Part 211/820Client Audit Programs

Common Audit Challenges

  • Managing compliance across multiple product types and clients
  • Change control systems that don't capture client notification requirements
  • Cross-contamination controls and equipment cleaning validation
  • Satisfying conflicting client quality agreement requirements
  • Maintaining inspection readiness for both FDA and client audits

Food & Beverage

FSMA transformed food safety regulation from reactive to preventive. Food and beverage manufacturers must now maintain preventive controls plans, supply chain programs, and documented hazard analyses — with FDA inspections to verify compliance.

ADF helps food manufacturers build and maintain FSMA-compliant programs that satisfy both FDA expectations and the third-party audit schemes (SQF, BRC, FSSC 22000) that retailers increasingly require.

Key Regulations

FSMAHARPCPreventive ControlsCGMP 21 CFR 117Supply Chain Program

Common Audit Challenges

  • Hazard analysis that doesn't address all known hazards
  • Preventive controls not properly validated or verified
  • Supplier verification programs with incomplete documentation
  • Environmental monitoring for Listeria and other pathogens
  • Recall plan readiness and traceability system gaps

Don't see your industry?

If your company is subject to FDA oversight, we can help. Schedule a call and we'll discuss your specific regulatory requirements.